2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P0034A
    Ac-DEVD-CMK TFA 99.07%
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis.
    Ac-DEVD-CMK TFA
  • HY-107494A
    all-trans-4-Oxoretinoic acid 38030-57-8 98.03%
    all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
    all-trans-4-Oxoretinoic acid
  • HY-113143A
    Galactose 1-phosphate Potassium salt 19046-60-7 ≥99.0%
    Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
    Galactose 1-phosphate Potassium salt
  • HY-124607B
    BRD3731 2056262-07-6 98.21%
    BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 is potentail for the research of post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes, and neurodegenerative disorders.
    BRD3731
  • HY-128851B
    Coenzyme A sodium 55672-92-9 99.46%
    Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.
    Coenzyme A sodium
  • HY-N1446S2
    Oleic acid-13C18 287100-82-7 ≥98.0%
    Oleic acid-13C18 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
    Oleic acid-13C18
  • HY-P10745A
    Petrelintide acetate 99.81%
    Perelintide (ZP8396) acetate is an amylin analog that shows potential for reducing body weight. Petrelintide can be used in diabetes research.
    Petrelintide acetate
  • HY-W012790
    Sodium 2-hydroxybutanoate 5094-24-6 ≥98.0%
    Sodium 2-hydroxybutanoate is an endogenous metabolite.
    Sodium 2-hydroxybutanoate
  • HY-W014423
    L-Histidine hydrochloride hydrate 5934-29-2 ≥98.0%
    L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
    L-Histidine hydrochloride hydrate
  • HY-W015608
    2-Phenylpropionic acid 492-37-5
    2-Phenylpropionic acid is an intermediate in alpha-Methylstyrene metabolism.
    2-Phenylpropionic acid
  • HY-W017163
    7-Methylxanthine 552-62-5 ≥99.0%
    7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity.
    7-Methylxanthine
  • HY-W018004
    L-Homocitrulline 1190-49-4
    L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
    L-Homocitrulline
  • HY-W048838
    Acetyl-L-lysine 1946-82-3 ≥98.0%
    Acetyl-L-lysine is an acetylated form of the amino acid L-lysine. Acetyl-L-lysine can participate in protein acylation processes, affecting protein functions such as stability and enzyme activity.
    Acetyl-L-lysine
  • HY-W194810
    MCU-i11 902903-59-7 98.42%
    MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth.
    MCU-i11
  • HY-111431AS
    p-Cresol sulfate-d7 potassium 2469278-96-2 ≥98.0%
    p-Cresol sulfate-d7 (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].
    p-Cresol sulfate-d7 potassium
  • HY-76801
    24, 25-Dihydroxy VD2 58050-55-8 99.89%
    24,25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a hydroxylated metabolite and derivative of Vitamin D2 HY-76542 (HY-76542).
    24, 25-Dihydroxy VD2
  • HY-18569A
    3-Indoleacetic acid sodium 6505-45-9 99.95%
    3-Indoleacetic acid (Indole-3-acetic acid) sodium is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis.
    3-Indoleacetic acid sodium
  • HY-N1428A
    Citric acid monohydrate 5949-29-1 ≥98.0%
    Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice.
    Citric acid monohydrate
  • HY-16397
    Phenformin 114-86-3 99.72%
    Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.
    Phenformin
  • HY-124899
    Hh-Ag1.5 612542-14-0 99.90%
    Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.
    Hh-Ag1.5
Cat. No. Product Name / Synonyms Application Reactivity